(Crossover: DC and Marvel) A World-Spanning Adventure

Joanna dreamed of becoming a hero. She and Jackie, her best friend since childhood, opened a Hero's Home specializing in vanquishing demons and evil spirits. But after Jackie introduced her boyfriend of two years, whom she'd been secretly dating, everything suddenly started going in the worst possible direction.

Joanna: "I've uncovered a world-shaking secret! I'm going to protect the world!! This is all the system's fault!"

Jackie: "Well said! That's my bro!"

Captain America: I want to get back together with my ex-girlfriend.

A story with two female leads. They're best friends all along, until they discover they aren't, actually.