Looking across the generations of Hokage, every one of them had a Uchiha bestie, whether or not things worked out between them.
The First and Uchiha Madara,
The Second and Uchiha Izuna,
The Third and Uchiha Kagami,
The Fourth and Uchiha Fugaku,
The Sixth and Uchiha Obito,
The Seventh and Uchiha Sasuke.
Only the Fifth had no girlfriend, not even a single Uchiha in sight. That's taking gender discrimination too far!
Transmigrate as a Uchiha bestie for the Fifth Hokage! Punch Kato Dan, kick Jiraiya, marry (or be married off to?) Tsunade-hime, and reach the pinnacle of life!
As an excellent Uchiha bestie, you must grow up with the Hokage you choose, sharing childhood and common interests, sealing your bond with a kiss, and competing with each other. Then you fight side by side, trust each other with your backs, take bullets for each other, and support one another. After that, your differing ideals drive you apart, and you trade insults at the Valley of the End before going your separate ways and fighting it out. Then you can't quite let go, chasing after each other, loving and fighting, and staying true to each other until death...
Uchiha Akiha burned the scrap of paper in her hand to ashes with a Fire Release jutsu. "Who'd want to be that kind of bestie? And is this a bestie or a lover? This is way too hard! The whole process is way too complicated!"
The author says the journey is full of twists and turns, but the ending is happy. Just go along with it ╮(╯▽╰)╭
* The top/bottom pairing for Akiha and Tsunade hasn't been decided yet. There may also be the Uchiha Three Couples: Hashirama/Madara, Obito/Kakashi, and Naruto/Sasuke. No switching and no breaking up the pairings.