The city had once been peaceful, but a series of strange incidents at its tourist attractions left everyone in a state of panic. An investigation by a special organization revealed that demons, long thought to have vanished, were behind it all. They were hatching a massive plot to strike back at the world.
Meanwhile, three high school students, deliberately guided by an unseen hand, met at their school. As they went about their school lives, they gradually formed the "Spirit-Slaying Trio" and embarked on a path to quell the crisis and save the world, fulfilling their mission to slay demons and monsters. Along the way, they fell in love with demons, searched for the truth about their own origins, and matched wits with both demons and monsters. They overcame one crisis after another, growing stronger each time and drawing ever closer to the truth of their origins, until they finally became Spirit Slayers capable of standing on their own...