Jin Zhongxiu has just graduated from college when his father asks him to learn the art of portraiture from his friend Wang Gu. Dutifully, Jin Zhongxiu goes to study. But just after mastering the craft, he sets up a stall outside to test his skills, only to be ambushed by a strange man. The old man, Wang Gu, subdues him, and the man turns into a beast before collapsing. The two bring him home, where the old man reveals that he is a Spirit Portrait Official and explains that he has little time left. Jin Zhongxiu takes on the responsibility of a Spirit Portrait Official, painting portraits for the divine realm, and becomes the apprentice of a true Spirit Portrait Official. He learns that his two grandmasters were killed by powerful gods. Around the same time, he receives a secret message left behind by his founding master. To uncover the truth and find the killer, Jin Zhongxiu and Wang Gu follow the clues left by the founding master, one step at a time. They face countless dangers and meet helpful allies, encountering everyone from supreme beings high in the heavens to vile and ruthless western demons. At last, they come face-to-face with the mastermind and bring everything to an end with their own hands...