After losing her life in an attack on a doctor, psychiatrist Chuan Lian transmigrates and becomes Feng Zhiyi, the ten-year-old only daughter of the late Prince of Zhennan. The emperor personally bestows upon her the title of Princess Titi, and she takes the tenth place in the royal line of succession. She thought she could enjoy a life of luxury without lifting a finger, but the palace is full of hidden dangers and complicated people. Even a princess cannot have everything go her way. Over the next five years, Feng Zhiyi is caught up in endless royal power struggles while also traveling the land as a renowned doctor, healing the sick and saving lives. Yet at fifteen, she is unexpectedly chosen as a princess for a political marriage, destined to fall into another treacherous palace. A life-and-death curse reveals her master's long-kept secret: a blood feud so bitter that it can never be forgiven. The master hopes to use their disciple to kill her betrothed, the crown prince of the Xishu Kingdom. The life-and-death curse is exactly what its name implies: one lives, one dies, and it targets only the first person to share a bed with its victim. But on New Year's Eve, the princess Feng Zhiyi shares her bed with him? Some loves are doomed from the very beginning.