The story follows A Fu, an ordinary young man afflicted with a strange illness. After seeking medical help everywhere to no avail, he begins searching far and wide for unconventional remedies in hopes of recovering. Along the way, he has many remarkable encounters that open his eyes to the wider world. He also happens upon an otherworldly master and gains insight into advanced civilization. Fighting his way through every obstacle and battling demons and gods in bloody conflicts, he succeeds in cultivating immortality and ultimately becomes a god.
