In the early years of the Republic of China, the country was ravaged by war. Zhang Jiji, a descendant of the Medical Sage, traveled far and wide in search of his ancestor's medical legacy and nearly froze to death before being rescued by the immortal master of Jilong Guan. After many twists and turns in his quest to reclaim the rare book Yu Li Zi, and inspired by brothers like Li Tianchi, he gradually set out on the path of saving his country and its people. He joined the Hongmen, took over the Axe Gang, punished traitors, and assassinated the Demon King, ultimately becoming the judge of a chaotic age and a great physician of his generation.