Wu Youke

At the end of the Ming Dynasty, Wu Youke resigns from office and returns to his hometown. When an epidemic breaks out, he decides to search for a cure. His wife, Yun Shu, wants to help him, so she devotes herself to studying Miscellaneous Sayings of a Female Physician. Thus begins their life as traveling doctors, sharing both hardship and joy.

As Wu Youke and his wife leave the capital, the world of the Ming Dynasty gradually unfolds. Its bustling street life, achievements in various fields, new ideas emerging within traditional culture, and cultural clashes with Western missionaries are all revealed through Wu Youke's work as a physician.