Modern truck driver Li Ergou dies in a car accident and transmigrates to the Qin dynasty, where he becomes an apprentice tasked with testing medicines under the alchemist Xu Fu. Xu Fu refines two secret elixirs of immortality for the First Emperor and forces him to test them. After blood pours from his seven orifices, he is abandoned in a mass grave. When he wakes, he discovers that he truly cannot die. To hide the secret, he assumes a false name and treads carefully, struggling to survive through a thousand years stretching from the Qin and Han dynasties to the Qing. Through changing dynasties, pursuit by martial factions, the covetous interest of alchemists, and the scrutiny of emperors, every step is perilous. Thus begins a twisting, thrilling legend of an immortal who does whatever it takes to stay alive.