At the end of the Eastern Han dynasty, the land is plunged into chaos. Cao Cao campaigns against his rivals in the name of the Han emperor, and just as his ambitions seem within reach, he suddenly falls ill with a severe headache. The famed physician Hua Tuo is imprisoned while trying to treat him. Before his death, Hua Tuo gives his treasured medical text, The Green Satchel Manual, to his close friend Ye Huairen. But Ye's wife accidentally burns the book, leaving only half of it behind. Armed with nothing but those remaining pages, Ye Huairen travels the land, practicing medicine and helping the sick. Everyone calls him Divine Physician Ye, and his fame soon spreads far and wide.
