Luke, a PhD in physics and chemistry, transmigrates to London in 1665 and from the start faces the double calamity of the Black Death and the Great Fire! Armed with modern knowledge, he's not worried in the slightest.
Watch me build an AK-47 overnight and sweep through the English Civil War, brew penicillin and monopolize Europe's black market, and make Newton question his whole life after sneaking a look at my manuscript of The Theory of Relativity!
Newton: Luke is the true god of physics. I wish I'd studied theology sooner!
Fermat: I spent my whole life studying mathematics, yet I haven't achieved even a tenth of what Luke accomplished in one night!
Royal Academy of Sciences: Lord Luke, to save all of humanity, you must wear this imperial robe!