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In the autumn of 1986, Chen Jianjun, the son of a Qitaihe miner, entered the May 17th dormitory of Harbin Medical University and became brothers with six teenagers with different ambitions. In the past forty years, they have grown from young medical students to doctors, managers, and entrepreneurs. They have gone through the test of life and death, the wave of medical reform and the baptism of the epidemic, and have stayed with them through ups and downs. This friendship, which is better than blood relatives, spans the ages of mountains and seas, and eventually becomes a human bond that will last a lifetime.

Shen Ruyi, a financial CEO in her previous life, was pushed off a cliff by her husband and best friend when she was seven months pregnant. She was reborn as a widow in Shaanxi in the late Qing Dynasty. The family is surrounded by poverty, the father-in-law is seriously ill, and the family members bully him. In order to sell the Wu family's tea, cloth, and persimmon cakes all over the country, she started from scratch and became a female business saint in Shaanxi. She was named a first-class imperial concubine by the Empress Dowager Cixi.