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Synopsis: A family curse, a countdown to the death of five generations of men at the age of 50. Genius emergency doctor Lin Shouren is the next "expiration date". When he discovered that behind the curse of the "fate mark", there was actually an amazing secret of the evolution of life hidden, he decided not to sit still and wait for death. He formed an alliance of "countercurrent people". What they have to fight against is not only the fate of genes, but also the doubts of the entire medical community and the hunting of commercial capital. When a 78-year-old man with the same mark on his palm appears, all clues point to a subversive truth: "Fate Mark" is not a death sentence, but an ultimate test paper about the limits of life left to the brave...