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At the end of the Ming Dynasty, Wu Youke resigned and returned to his hometown. When the plague was prevalent, he decided to find a cure. In order to help her husband, Mrs. Yun Shu painstakingly studied "Miscellaneous Words of Female Doctors", and from then on, the couple shared the joys and sorrows of traveling as a doctor. As Wu Youke and his wife leave Beijing, the picture of the Ming Dynasty slowly unfolds. The city life of the Ming Dynasty, achievements in various fields, new trends in traditional culture, and the cultural collision with Western missionaries will all be presented in Wu Youke's medical practice.

In addition to Confucianism, Buddhism and Taoism, remnants of hundreds of traditional schools of thought still exist, and there are even new developments. Western missionaries are not willing to be left alone, traveling thousands of miles to preach. This was an era in which a hundred schools of thought contended. It was different from the Chinese field of the Spring and Autumn Period and the Warring States Period, and also different from the Eastern and Southern Asian fields of the Wei, Jin, Southern and Northern Dynasties. The contention of a hundred schools of thought in the late Ming Dynasty was not limited to China or East Asia. It was Chinese and Asian, and it was a grand intellectual event in the world. Please come with me back to the eve of the contention of a hundred schools of thought in the late Ming Dynasty and relive the prosperity of the late Ming Dynasty.