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During the Wanli period of the Ming Dynasty, in order to celebrate the sick and frail eldest son of the Wan family, while the head of the family, Mr. Wan, was out looking for precious medicinal materials, Mrs. Wan found the "living medicine" widow Fang Yan to marry the eldest son in a hurry. Meanwhile, the second wife of the Wan family had a difficult childbirth and was in critical condition. Fang Yan and her mother-in-law Jiang Shan had no choice but to go into the hospital to prescribe medicine, causing public outrage. Fang Yan was forced to divorce her husband and leave. The second young master used folk remedies to please the officials, but unexpectedly caused the death of his family members, and the Wan family was convicted and exiled. Mr. Wan couldn't bear the suffering of his family and divorced his wife on the grounds that the third young master was not his biological son. The Wan family has been torn apart since then. In order to repay the kindness of her mother-in-law Jiang Shan, Fang Yan went north to look for Mr. Wan. On the way, Fang Yan practiced medicine and applied medicine and learned about various schools of medicine, and his medical skills became more sophisticated. After learning that Mr. Wan was dead, the mother-in-law and daughter-in-law decided to open a medical clinic as a female doctor to revive the Wan family. Wanjia Medical Clinic helped the common people and gained a reputation. However, it was framed due to a dispute over folk remedies and was convicted again, facing the disaster of being executed. The mother-in-law and daughter-in-law worked together to overcome the crisis, cleared away the fog, and finally found out the truth.