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The online video of a girl desperately clawing at the top of a box sealing her off is the most brutal crime FBI forensic psychologist Zoe Bentley has ever seen in her life, and perhaps most puzzling is the video's title: "Experiment One." Zoe and her partner, Agent Tyten Gray, race to find the shadowy figure behind the shocking video, but soon another video appears online and another girl dies. At the same time, Zoe still has a murderer in her heart that she is determined to catch. The killer named Rod Glover has been tormenting Zoe's psyche since she was a girl, and his latest attack was a threat posed by a photo of him and Zoe's sister. As Grover shifts from stealth to action, Zoe feels physically and mentally exhausted between family ties and responsibilities. Although Zoe has always known that her job will bring her life and death, she still feels that she will live towards death.

The demon Rod Glover has committed a series of murders. Twenty years ago, his crimes were exposed by Zoe, a teenage criminal psychologist, but he cunningly escaped and kept threatening Zoe. With the frequent occurrence of blood-sucking cases, Zoe's residence was also broken into. She and agent Tatum found Grover's hiding place, and accidentally discovered that Grover had a terminal brain tumor and had become an out-of-control bloodthirsty maniac. He also controlled a psychopathic photographer, who fantasized about drinking human blood to cure his illness, and was induced and used by Glover to commit murder. In order to prevent this horrific crime, criminal psychologist Zoe and the murderer Glover launched a final showdown...