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This book is an easy-to-understand medical history that integrates anthropology, civilization history, medical thought, medical conditions, doctor figures, folklore and the history of human disasters. It tells the history of plague and the spiritual history of mankind's fight against plague. It comprehensively recalls the characteristics and processes of various plagues that humans have faced from ancient times to contemporary times, profoundly reveals the relationship between the progress of medicine, the power of viruses, and the evolution of civilization. It provides a blueprint for humans to understand the true face of plagues and provides reference experience for preventing and controlling plagues. History has proven that eras without plague are rare. Humanity has always been accompanied by plague. In other words, plague is a part of human life and an opponent that human beings will always have to fight against. The work of Howard Macell proves the assertion of Pasteur, the father of virology: "The laws of plague and death are always imagining new means of destruction, while the laws of peace, work, and health are always seeking new ways to save mankind from plague.