After Constantine established the new capital of the "Roman Empire" on the Bosporus on the east coast of the Mediterranean, by the time of Justinian, it had experienced more than 200 years of intense turmoil. At this time, the Eastern Mediterranean region centered on Constantinople had actually broken away from the development trajectory of the Latinized Roman-Mediterranean Empire centered on the city of Rome. In terms of development in various fields of politics, economy, culture, and religion, it basically possessed the characteristics of the medieval Byzantine Empire, and laid the foundation for the development of Byzantine history in the following 1,000 years.