A beautiful girl Qian Mian suddenly disappeared, and her roommates actively searched for her. However, they accidentally discovered a secret: the girl's family has a history of depression. The story tells the different love stories and different destinies of three generations of their grandparents. Grandma Wenxia was a primary school teacher deeply influenced by traditional thinking. She was entrusted by her benefactor's daughter, the wife of a deputy commander, to take care of her three sons after she became a prostitute and lost her freedom in life. On a night of thunder and lightning, she was raped by the deputy commander and got married. She suffered from depression due to self-blame and guilt, and spent an unhappy life on the hospital bed. Her mother, Ming Yinghong, was beautiful and capable. In order to take care of her family, she also became a primary school teacher. After her mother Wenxia passed away and her father remarried and gave birth to a daughter, Qian Mian, she suffered from postpartum depression, received treatment and recovered. However, when her husband died of carbon monoxide poisoning in the car due to an affair, his depression relapsed under the huge negative impact, and he jumped off the building to commit suicide in despair. When her mother passed away, the girl discovered that she was also suffering from depression. In order not to drag her boyfriend down, she proposed to break up with her.