Rui Jinxi, a doctor of modern medicine and poisoning, accidentally traveled through time and became the infamous nymphomaniac daughter of the Great Yong Prime Minister's Palace. She was framed at the beginning and was offered a marriage by the queen to Mo Yunce, the crown prince of Prince Xuan who was poisoned by a strange poison and whose face was covered by a mask. With her medical skills and wisdom, she broke up bad relatives, practiced medicine to investigate cases, started a business and made money, and managed every step between the deep house and the court. The two went from being an agreed couple who disliked each other to teaming up to uncover the truth about old cases and poisonings. They gradually fell in love amidst the turmoil, and finally redeemed each other, protecting their homeland and each other.
