Twelve years ago, Su Heng accidentally cured a poisoned palace nobleman and was involved in a harem poisoning conspiracy. In order to cover up the crime, Concubine Zhao teamed up with the princelings to frame the Su family and created the "Su family poison murder case", killing everyone in the family. Su Jiu was sent away early by her father because she was young, and was taken by an old servant to live in seclusion in the south of the Yangtze River. Later, she studied under a famous reclusive doctor.