Gu Changsheng traveled to the Great Yan Dynasty and activated the "Tiandao Death System". In order to complete the task, he proposed marriage to Li Cangyue, the powerful princess of the Supervisory Kingdom, in the Golden Palace. He unexpectedly became the consort and was involved in the vortex of the change of imperial power. Gu Changsheng relied on system rewards to obtain Shen Nong's Baicao Jing, and also found the evil power "Ten Thousand Poisons Jing", embarking on the road of "poison swallowing and upgrading". In the name of treating the emperor, he searched for banned drugs from the imperial hospital and secretly cultivated a poisonous body that was invulnerable to all poisons. With his strange poisonous skills, he defused the assassination attempt by the second prince's gang and helped the princess clear out her political enemies. The two gradually develop a tacit understanding and affection. As the eldest prince, who holds military power, returns to the court, the power crisis in the capital rises again.