Huang Jiayu, a boy from Northeast China with all negative characters in his horoscope, was rescued by Sanxian Cui Bancheng when he was young, and was bound to the family of Mangxian Bao in his life. When his mentor died at the age of twenty, he went to Luoyang with three testaments and was not allowed to return home for three years.
A girl with a strange disease, an insect under the skin, and a family of traditional Chinese medicine compete with each other. The fledgling brother Ma Yisheng is born to open his eyes and break through the situation. He walks out on his own path of immortality amidst the debts of karma.