Su Huang, a modern medical and poison expert, dressed as the legitimate daughter of the Hou family who was abandoned in a mass grave on the day of her wedding. She was poisoned, her mother was killed, and her sister took her place as the regent. She went from being anonymous and practicing medicine to survive in a border town to returning to the capital with unparalleled medical skills and ingenuity. Faced with the murderous hands of her stepmother, the family's conspiracy and the undercurrent of the court, she and the thoughtful regent Chu Yu, who made a three-month agreement with her, went from testing each other to becoming allies. Using her medical skills as an edge and her benevolence as a shield, she opened a medical clinic, set up a school for girls, broke monopolies, eliminated imperial hospitals, and was even involved in the turmoil between the imperial power and her relatives. This is a counterattack from the house to the world. A generation of miracle doctor Huang Fei will eventually cure this era and gain power over the world.