Chen An, a top surgeon at a major hospital, wakes up to find himself transmigrated into the Ming Dynasty, where he is a lowly servant at the Imperial Medical Academy, stuck scrubbing medicine jars. Before he can figure out what's going on, eight-year-old Zhu Xiongying, the emperor's eldest grandson, suddenly falls gravely ill. The Imperial Medical Academy is helpless, and Zhu Yuanzhang flies into a rage, ordering two heads cut off: “If you can't cure him, you'll all be buried with him!”
Everyone drops to their knees. Only Chen An steps forward. “This commoner can treat him.”
Zhu Yuanzhang sneers. “A mere servant?”
Chen An meets the emperor's gaze. “If Your Majesty doesn't believe me, this commoner can leave right now. Besides, I won't be the first one beheaded.” With that, he leaves the Hongwu Emperor speechless.
After being given penicillin, Zhu Xiongying wakes up. But before Chen An can catch his breath, Zhu Yuanzhang's sword is at his chest. “Speak. Who sent you?”
At this critical moment, Zhu Biao drops to his knees. “If Father wants to kill him, then kill me first!”
From then on, a lowly servant becomes the Crown Prince's sworn brother. He treats Empress Ma, mouths off to Zhu Di, curses out Lan Yu, reforms the Imperial Medical Academy, and promotes new farming tools. Chen An runs rampant through the Ming Dynasty, with the entire Eastern Palace backing him. Zhu Yuanzhang grits his teeth. “I've never bowed to anyone in my life, except for you, you rascal!”