Shen Zhiyi, the chief surgeon in the emergency department, was falsely accused of killing a patient who suffered from sudden heart failure. Faced with accusations from the entire Internet, she used a scalpel to cut open the body on the spot and proved her innocence, which shocked the country. Forensic doctor Lu Zhaolin holds key evidence but remains silent, head nurse Lin Yanqiu secretly monitors the truth, and Su Tang, the orphan of the deceased, sneaks into the hospital quietly, just for revenge. When the medical system, pharmaceutical giants and judicial bias work together to cover up the truth, Shen Zhiyi must use the tip of a knife to tear apart the layers of shady amidst the betrayal and separation of relatives, and every silence from Lu Zhaolin may become the last straw for her.