Xie Zhaoning, the legitimate daughter of the Xie Mansion, was sentenced to death due to her father's involvement in a corruption case. She was replaced by her stepmother and married to Xiao Chengjun, the terminally ill King of Zhenbei, instead of her half-sister. On their wedding night, her identity was discovered by her husband, and all her chances of survival were cut short by "giving him poisonous wine." After faking her own death and escaping, she sneaked into the Jianghu incognito and stirred up troubles as a "ghost-hand poison doctor", secretly tracing the truth behind her father's injustice. When she returned to the capital with evidence in hand, she discovered that her true life experience was involved in a shocking palace incident twenty years ago, and that the sick prince had been her most dangerous ally and deepest obsession from the beginning to the end. What she wants is not justice, but the world playing chessboard.