In the twenty-seventh year of the Republic of China, Yunling Fortress fell. The elite divisions of the Japanese army controlled the natural dangers of the Yangtze River, and the people survived in dire straits. Shen Danning, the young boss of Jishitang, appears to be a Buddhist young man who only wants to keep his ancestral medicine shop, but in fact he is the most secret intelligence agent of the underground party of the Chinese Communist Party. He is proficient in poisons and antidotes. He can exchange a piece of poison for a piece of information, and he can kill a traitor with a packet of poison powder. Masao Watanabe, the director of the Special High School Course, regards him as a thorn in his side, and the genius spy Lin Hansheng is closing in on him step by step. What's even more troublesome is that his younger brother Shen Danchuan returned from the Japanese Army Non-commissioned Officer School and became a new agent in the Super High School. Brothers meet again, each his own master. When Shen Danning received the task of assassinating a traitor, he found that the target was protected by Shen Danchuan. When the Japanese army launched the "Sakura Project" to prepare for germ warfare, Shen Danning had to develop an antidote formula within three days - while Shen Danchuan was guarding the door of the drug store with handcuffs. The fireworks in the medicine stove have not yet been extinguished, and the secret war has already heated up. Can he use his hands to save the people and keep his faith?