In 1932, a strange plague broke out in Zhangjiakou. Doctor Cuiniang discovered that it was a poisoning plot by the Japanese Army's Unit 731. Police detective Guan Qingtian, wealthy businessman Gao Xiuxuan, and foreign doctor Frank jointly attacked and found that the enemy was spreading modified bacteria and viruses through well water and fake pills. They broke into pawn shops, destroyed pharmacies, fought bloody battles with spies, revealed the truth about germ warfare, stopped the epidemic with their flesh and blood, and protected the safety of the people in the city.