Xu Qinghuan was originally a wealthy daughter of the imperial hospital. When he was ten years old, his father's home was confiscated and exiled because he was involved in the "Golden Chamber Case" in which he was seized by the imperial court. She was rescued by a loyal servant who risked his life and hid among the people. She changed her name, studied medicine and tactics, and ran a medicine house in the mist of Jiangnan. On the surface, she is a cold-blooded medical woman who helps the world. In fact, every patient she treats is a chess piece laid out by her - either a fallen general or an abandoned secret guard. Many years later, when the upstart of the imperial court once again set foot in the south of the Yangtze River to seek medical treatment, she knew that the time had come to close her net. What she wants to return to is not only the center of power, but also to tear apart the truth of the year with her own hands and restore the Xu family's innocence.