A strange plague broke out in Qingshi City, and medical girl Shen Guiyan discovered that it was poisoning. In order to investigate the cause of her grandfather's death and the injustice of Prince Jing, she set out on the road to the capital. On the way, he met Gu Beichen, an old subordinate of King Jing. The two worked together to solve the conspiracy, find evidence of guilt, and fight against the uncle of the country. They went through life and death to clear the grievances of King Jing, protected the common people with their medical skills and integrity, and gained a deep love for each other.