Shang Jingxing is the young owner of Jirentang, the largest medicine dealer in Jiangzhou. He has suffered from heartache since he was a child, and the medicine has no effect, and he has low self-esteem. One night, he fell ill on the street and was rescued by Shen Ruolan, a medical girl who had returned from collecting medicine. Shen Ruolan used Qingsang silver needles to relieve her pain; Shang Jingxing learned that she was the only descendant of the Qingsang sect and had superb medical skills, so he hired her with a lot of money; Shen Ruolan was not allowed to make friends with merchants due to the instructions of her master, but she saw that Shang Jingxing was sincere. Gentle and humble, he made an exception and agreed; the two gradually got to know each other during the process of diagnosis, dispensing and testing medicines; Shang Jingxing discovered that Shen Ruolan seemed cold but was actually attentive, and Shen Ruolan admired Shang Jingxing's optimism and perseverance despite being tortured by illness; Shang Jingxing's uncle, Shang Huaiyuan, colluded with Jishitang and deliberately raised the price of medicinal materials in order to sideline Shang Jingxing; Shen Ruolan used Qingnangmen's drug farmer channels to help Shang Jingxing purchase medicinal materials at low prices to resolve the shortage. Crisis; Shang Jingxing was grateful, but his condition suddenly worsened. Shen Ruolan did not hesitate to use the forbidden technique of "Yin Yang Reverse Needle" to save her, and she fell into a coma; Shang Jingxing guarded Shen Ruolan day and night, and the relationship between the two changed. After Shen Ruolan woke up, she received an anonymous letter stating that Shang Jingxing's biological father was the Qingsang traitor who poisoned her master; Shang Jingxing was actually the orphan of an enemy adopted by Shang Huaiyuan; Shen Ruolan painfully questioned Shang Jing OK, the relationship between the two broke down; Shang Jingxing cleared the suspicion, secretly investigated his father's relics, and found that the poison in the jade pendant was consistent with the poisoning by his master, but the bigger culprit was Shang Huaiyuan; at this time, a plague broke out in Jiangzhou, and Qingnangmen and Jirentang were asked by the government to help; Shang Jingxing and Shen Ruolan were forced to cooperate and re-establish trust in treating patients; Shang Jingxing found an ancient antidote by testing poisons on his own, and Shen Ruolan developed a medicine.