Shen Qingyuan, the legitimate daughter of the Shen family, was framed by her concubine and concubine Shen Zhilan. Her whole family was wiped out and she died of hatred. Once she was reborn and returned to the age of fifteen or sixteen, she opened a medicine shop in the capital under the pseudonym Mo Yuan. She relied on her previous skills as a doctor and poisoner to survive in seclusion and was determined to take revenge. Gu Beichen, the prince of Zhenbei Hou who was seriously injured and on the verge of death, was sent to Yaolu. Shen Qingyuan rescued him with a medical fee of 100,000 taels, but unexpectedly got into trouble with this powerful prince. Gu Beichen fell in love with her at first sight, silently guarded her and supported her in every way. He not only helped her resolve the frame-ups and plots of her concubine, but also accompanied her to find out the truth about the Shen family's destruction. On the road to revenge, Shen Qingyuan went from being an orphan who was bent on revenge to being gradually moved by Gu Beichen's deep love. The two of them joined forces to tear apart their enemies and expose the conspiracy. In the end, Shen Qingyuan killed his enemies with his own hands, brought peace to the Shen family, and gained a sweet love with Gu Beichen.