The story takes place in the world view of Liuhe Baji. The protagonist Chen Jiugong was originally a herb gatherer from a "farmer's family". Because he rescued a righteous disciple who was injured by a "poisonous cultivator", he was framed as a member of the poisonous cultivator. His disciple was wiped out, and his own meridians were eroded by the strange poison of "Zhou Xing Bu Ba Ji", and he was on the verge of death at the age of forty. In a desperate situation, deep in the Duiji Illusory Mist Swamp, he accidentally obtained the ancient poison cultivator's inheritance "Wen Xing Lu" and "Hongmeng Purple Qi Talisman", and was forced to embark on the dangerous path of fighting poison with poison and cultivating immortality with poison.
In the process of practicing, he met Zhi Lu, a cold-faced sword cultivator who left the "Legal family" due to different ideas, and Bu You, a girl from the "Yin Yang family" who traveled in pursuit of the balance between heaven and earth. The three of them team up to face the continuous pursuit from the righteous path, the erasure of "variables" by the enforcers of order, and the invasion of the territory of the monster king. Chen Jiugong uses poisonous techniques to solve difficult and complicated diseases and treat mortal monks who have given up on orthodox medical skills. He is gradually involved in the dispute over the "Nine Origins" - the ultimate debate between the nine major schools of thought on "the origin of the world."
In the end, Chen Jiugong sublimated the way of "poison" to the principle of "medicine", used the "Wuji Golden Pill" to accommodate all kinds of poisons, evolved endlessly, and understood that the true meaning of "The Stars Confined Immortal Forbidden City" is not a trap, but a "definition". He did not choose to destroy order or surrender to chaos. Instead, he opened up a third path that allowed "orderly evolution" within the framework of Liuhe and Baji. He became the "Star Questioner" who connected the nine streams and reconciled order and chaos. He found the destination of "seeking changes in rules and establishing rules in changes."
