The story takes place in the last years of the fictional 'Dayin' dynasty - the rites and music of the Central Plains collapsed, the Miao border witchcraft disappeared, and the ancient heritage remained silent for thousands of years. Hua Jinghong, a young medicine boy, was collecting herbs in Yunwu Mountain and accidentally fell into the cave of ten thousand snakes. He accidentally awakened the poison spirit transformed by the ancient witch ancestor "Zhu Yin" who had been sleeping for three thousand years. He was originally the last witch king bloodline whose clan was exterminated by the 'Jing Wu Si' using the 'Heart-eroding Gu Formation', but he used pharmacology to enter the gu and refined the poison with benevolence, rebuilt the witch alliance in the Shiwandong Village in the Miao territory, and set off a bloody storm in the Central Plains. The main plot revolves around finding out the truth about the genocide, recasting the Witch King's seal, and dismantling the pseudo-Taoist sect "Xuanqionguan" that controls the imperial power. Finally, the ancient true meaning of "Gu is not a method of harming people, but is actually the law of breathing of heaven and earth" is revealed.
