Yun Shuyao, a modern medical expert, is caught in an accidental laboratory explosion and transmigrates into the body of the bullied legitimate eldest daughter of the Chancellor's household in the Great Jing Dynasty. The original owner was timid and died miserably. Upon awakening, Yun Shuyao takes down her scheming half-sister, gives her vicious aunt a piece of her mind, and sees through the Third Prince's attempts to use her, severing their ill-fated relationship without hesitation.
A single diagnosis reveals that her bedridden mother is not frail by nature but has been poisoned with a slow-acting secret toxin! The case also leads to a shocking massacre from ten years ago, when the Su and Fu clans were framed and wiped out.
The Fifth Prince, Xie Qingyan, has spent ten years lying low, appearing carefree and useless. He is in fact the last survivor of the Fu clan. With his mother poisoned to death and his family falsely accused, he has secretly built up his strength, all for the sake of revenge and clearing his family's name.
Two formidable allies join forces to break the deadlock with medicine and poison, as household intrigue and political maneuvering unfold side by side. The heroine uses modern medicine to unravel the secret poison and uncover the truth, while the hero uses his hidden network to protect her and clear away obstacles. Step by step, they expose the conspiracy from ten years ago, quell the rebellion, and clear their families' names.
After the new emperor ascends the throne, the heroine takes charge of the Imperial Medical Bureau, promotes modern medicine, and saves countless lives. The emperor and empress stand together, using medicine and political acumen to usher in a golden age and create a legendary tale!