Shen Qingge is the concubine of the Marquis of Yong'an. She was framed by her aunt Wang and her sister Zhao Lingyun for stealing a jade pendant. She was beaten and expelled from the Marquis' mansion. When Xue Ye was about to die, she accidentally obtained the inheritance and medical system of the Yaozu, and awakened to the heaven-defying medical skills.
She rescued the regent Xiao Yehan who was seriously injured and poisoned in a ruined temple, and used silver needles and systems to forcibly stabilize his life. Xiao Yehan gave her a black iron token as a thank you gift.
Desperate, Shen Qingge entered Baicaotang in Beijing to work as an oddball. With her superb acupuncture and detoxification skills, she successively saved patients who were sentenced to death by the imperial doctor. She slapped the old doctor who made things difficult for her, and was accepted as a disciple by Lu Chenzhou, the young minister of Dali Temple, who gave him needles to teach her skills.
She established herself in the Imperial Hospital with her medical skills, entered the palace to treat the Queen Mother, exposed the shady story of the Imperial Hospital's shoddy medicinal materials and poisonous elixirs, slapped Zhao Lingyun in the face, and was named the Queen's Medical Woman by the Queen Mother, with free access to all the medical classics of the Imperial Hospital.
As her medical skills improved, she discovered that the poison Xiao Yehan suffered was the heart-eating poison of the Holy Medical Sect, and the Zhao family was the branch of the Holy Medical Sect in the capital. They colluded with the third prince and intended to use the poison to control the regent and subvert the court.
Zhao Lingyun designed to frame Shen Qingge many times (poisoning, setting traps, slandering), but Shen Qingge relied on his medical skills, system and the protection of the regent and Lu Chenzhou to resolve them one by one.
While Shen Qingge healed Xiao Yehan's wounds, he counterattacked step by step in the court and the imperial hospital, exposing the Zhao family's conspiracy to smuggle banned drugs, collude with the Holy Medical Teaching, and murder the royal family. In the end, during the civil strife and rebellion in the palace, he rescued the prince, calmed down the turmoil, completely slapped the Hou Mansion and the Zhao family in the face, and became a powerful medical concubine, working with Xiao Yehan in both directions.