In Tianjin and Hong Kong from 1919 to 1929, China and the West blended together, with undercurrents surging. Zhou Mingxuan, who returned from studying abroad, combines modern forensic science, chemistry, traditional criminal justice, and traditional Chinese medicine wisdom to open a detective agency to solve strange cases! Murders in secret rooms, serial poisonings, embassy assassinations, cult sacrifices, and unsolved cases progressed layer by layer, from urban mysteries to transnational conspiracies, finally revealing the shocking layout of the mysterious organization "Xuan Ming Hui". He teamed up with Liao Zhi, the criminal police captain who was a former Qing agent, and his wife Gu Wanqing, who is talented in chemistry. They relied on an intelligence network composed of informants and technical experts in the city, used scientific investigation to collide with traditional experience, and used hard-core physical evidence to decipher the conspiracy of the people. In troubled times, Eastern wisdom is integrated with Western science, and the layers of mystery in the depths of Tianjin and Hong Kong are uncovered. A brain-burning and thrilling detective feast begins!