In the deep palace of the Dajing Dynasty, everyone knew that Su Lingxi, a young doctor from the Huanyi Bureau who had just entered the palace, was an anomaly. She carries an old medicine box on her back and always likes to dig into the abandoned gardens of the cold palace. Her fingertips can make withered poisonous weeds bloom in an instant, and can also make the most popular concubine look haggard overnight. What's even weirder is that she can hear the whispers of the herbs and see the remaining obsessions of the deceased - the bloody mandala that grows wildly in the concubine's bedroom, always repeating the whisper of "not me" at midnight; and in the dry well in the imperial garden, the water-soaked medicinal residues will piece together the face of the missing palace maid.
No one knows that Su Lingxi entered the palace just to find her sister who died mysteriously and suddenly five years ago. It is said that her sister's death is closely related to the prince's seizure of power and the secrets of the harem. She dealt with the concubine who concealed a knife in her smile and the eyeing kings, using poisonous skills to save people and medical skills to kill people. However, when she was detoxifying the third prince Xiao Yu, she discovered that he actually had half a jade pendant of the same style as her sister hidden in his sleeve. When supernatural medical skills broke through the palace conspiracy, and when there was a blood feud hidden under the guise of strange spirits, Su Lingxi was shocked to realize that within the red wall, the most poisonous thing was never the medicine, but the human heart - and she was already on the way to find the truth, and was involved in a power vortex that was related to the lifeline of the dynasty.