Tao Xiaodie, a descendant of the ancient poison medicine sect, died in an accident due to a poison test. His soul traveled to modern times and became the "tool bride" of the wealthy Guo family for the sick eldest son Guo Zhenshuai. On their wedding night, she found that this "sick boy" was not only lively and active, but also exposed her "ulterior motives" in public - it turned out that he was also testing her background.
The two of them each have their own hidden agendas, and are forced to join forces to deal with the covetous forces of the second wife within the Guo family, as well as the frequent external crises of mysterious poisoning and murder cases. Tao Xiaodie repeatedly solves strange cases with her poison skills, but Guo Zhenshuai appears to be a playboy but hides his secrets. The main line is the emotional line between the two from scheming against each other to relying on life and death; the auxiliary line is the grudges between the Poison Medicine Sect and the ancestors of the Guo family a hundred years ago, which secretly points to a shocking secret - there is a peerless poison hidden in the Guo family's bloodline, and Tao Xiaodie's time travel is not an accident.