"Home with Kids" uses a blended family as the setting for its story. The protagonist, Xia Donghai, once accompanied his former wife to the United States, where he worked while she studied. After their divorce, he returned to China with his seven-year-old son, Xia Yu, and reunited with his daughter, Xia Xue, who had grown up in China. He later married Liu Mei, a head nurse at a major hospital. Liu Mei was also divorced and had a son named Liu Xing. The main story unfolds within this unusual family. Xia Donghai and Liu Mei are both loving and devoted to their children's upbringing. They hope to combine their love and wisdom to raise a happy next generation.