"Family with Children" uses reorganized families as the platform for the story to unfold. The protagonist Xia Donghai once followed his ex-wife to study in the United States. After the divorce, he returned to China with his 7-year-old son Xia Yu and reunited with his daughter Xia Xue who grew up in China. Later, he married Liu Mei, the head nurse of a large hospital. Liu Mei was also divorced and had a son named Liu Xing. The main story of this drama takes place in this special family. The common characteristics of Xia Donghai and Liu Mei are that they are caring and caring about their children's growth. They hope to "integrate" their love and wisdom to cultivate the next generation of happy lives.