Shen Qingtang was reborn with the memories of his past life, and returned to the eve of Ji Li's death when he was poisoned by Aunt Liu. He accidentally activated the poison detection system, which was able to scan for toxins and find solutions, and also unlocked the space of the portable medicine field. She relied on the system to identify poisonous bird's nests, and even discovered that Aunt Liu was looking for a gold-inlaid jade button related to the cause of her mother's death.
She formed an alliance with her younger brother Mingxuan to fight against Aunt Liu. When investigating the poisoning case of Aunt Li, she discovered that licorice can detoxify hundreds of poisons. As the Haitang murder case occurred, the blood beads turned into red mist, the poison detection system unlocked new abilities, and the secrets of the mansion gradually emerged. The strange whereabouts of the mute woman and the shadow eavesdropping outside the window all hint at a deeper conspiracy. Shen Qingtang is planning a counterattack while tracing the truth behind his mother's death. He is determined to avenge his enemies and change his destiny amidst the murderous plots in the Hou Mansion.