The guide, Grandpa (Lin Zhengtang): is not an ordinary barefoot doctor. When he was young, he might have been a famous "ghost-hand doctor" in the "other world", but because he was unwilling to join in the conspiracy, he was plotted and kept his name anonymous. His diary is the most precious clue left to the protagonist.
· Old enemy·Gu Qinghong: Heir to a medical family, young, promising, and personable. He regards the protagonist as a "little guy" who breaks the rules, and is the protagonist's best benchmark and source of pressure in the early stages of the "Table World". His existence can push the protagonist to climb upward.
· Confidante·Su Muxue: The daughter of a pharmaceutical group, with a cold appearance but a kind heart. She initially approached the protagonist for business purposes, but as they got along, she was impressed by his personality and medical skills. She became an important bridge between the protagonist and the resources of the upper class in the city.
· Comrade Tieniu: The protagonist grew up in the slums, has a strong body and a loyal character. He is the protagonist's most solid backing, taking on all the roles of "protection by force" and "responsibility for the atmosphere".