Shen Miaoyi, a modern medical genius, died unexpectedly. When she woke up, she was a desolate medical concubine who had been abandoned in the Dayin Dynasty. Not only was he poisoned at the beginning, but he also faced the desperate situation of his mother's family being framed and executed. With her lost miraculous medical acupuncture skills, she first saved herself from fire and water, and then rescued the dying prince at the Queen Mother's birthday party, becoming famous in one fell swoop. Facing countless conspiracies and deadly poisons in the deep palace, Shen Miaoyi remained calm, using needles as blades and medicine as shields to kill the concubines who plotted against her one by one. And Xiao Chengyuan, the ruthless emperor who was suspicious by nature and suffered from hidden diseases, went from being initially suspicious and tempted to being completely defeated. In the end, he was willing to abolish the Sixth Palace for her, only seeking the only antidote in this life.