In the early years of the Dayong Dynasty, the imperial power was initially established, but undercurrents were surging. The remnants of the previous dynasty were hidden, and the traitors in the court were causing trouble. The family of Su Jin, the head of the Imperial Medical Office of the former dynasty, was framed for colluding with the former dynasty's forces and secretly developing a poison, and was framed for treason and treason. The whole family was executed. Only the legitimate daughter Su Qinghe and her grandmother were rescued by their loyal servants. Since then, they have been anonymous and opened a "Qingnang Medical Clinic" on the outskirts of the capital, using the pseudonym "Qinghe" to treat people with superb medical skills. They secretly collected evidence that the family had been wronged and waited for opportunities to seek revenge.
The heroine Su Qinghe is cold and restrained, thoughtful, proficient in internal medicine, toxicology and acupuncture. Her fingertips can not only save lives and heal the wounded, but also decipher poisonous schemes and conspiracies. She does not rely on others, and relies on medical skills as the foundation for her life. She has a difficult balance between "the benevolence of a doctor" and "blood feud". She has both the forbearance to hide her life experience and the decisiveness to face the conspiracy. She breaks the weak stereotype of traditional medical women and becomes her own backer.
The male protagonist, Xiao Jingyuan, is the reigning Prince Jing and the emperor's younger brother. On the surface, he is laid-back and gentle, and is obsessed with landscapes, calligraphy and painting. In fact, he is a secret agent secretly entrusted by the emperor. He holds the secret guards of the capital, and is responsible for clearing out the traitors in the court and investigating old cases from the previous dynasty. He understands medical science and is a strategist. He approached Su Qinghe in the early days because he suspected her identity as a remnant of the Su family. However, in repeated confrontations, he was attracted by her medical skills, character, and tenacity. From testing and using each other to fighting side by side and loving each other, he became her most solid support on the road to revenge. The two staged an affectionate bond that was evenly matched and redeemed each other.