This novel is about Nangong Xiyue, a medical prodigy equally skilled in medicine and poison. After being sabotaged by a villain, she transmigrates into the body of Shangguan Xiyue, the eldest daughter of the Shangguan family. Blessed by the Heavenly Dao at birth, Shangguan Xiyue possesses the Shangguan family's unique ethereal spirit root. She was ambushed and killed in a secret realm, but the Heavenly Dao preserved her soul and gave her a System. When Nangong Xiyue transmigrates into her body, she becomes the System's Host. The System requires her to survive until the story's end. Relying on the Shangguan family's status and fortune, Shangguan Xiyue becomes the third Child of Fortune. The other two are Lin Zhaoxue and Xiao Lingxiao. In the original story, the Shangguan family falls into decline and the Xuantian Continent is sealed off, making ascension impossible. The highest cultivation level is the peak of the Deification Realm. In the end, the two Children of Fortune, Lin Zhaoxue and Xiao Lingxiao, die defending all the people of the world from invasions by the demon race and other races. After transmigrating, Shangguan Xiyue decides to change the original ending. She and her maid Yue Ling join the Xuanling Sect: Yue Ling joins the Sword Peak, while Shangguan Xiyue goes to the Pill Peak. By chance, Shangguan Xiyue rescues Lin Zhaoxue from a mire, and the two become sworn sisters. Later, the five of them, along with Lin Yueze, the senior disciple of the Pill Peak, and Xiao Lingxiao of the Sword Peak, set out on their journey. They draw ever closer to the truth and work to stop the invasion of the demon race and other races.