"Ups and Downs" tells the ups and downs of the three generations of the Chen family in Linxi Town, an ancient town in the south of the Yangtze River, from the Cultural Revolution to 2020, showing the vicissitudes of Chinese society in half a century. Using family stories as a microcosm, it reflects the grand narrative of reform and opening up, and explores the intertwined relationship between individual destiny and the tide of the times. From 1966 to 2020, for half a century, three generations of the Chen family have been ups and downs, struggling, persevering, and moving forward in the wave of the times. They have experienced the turmoil of the Cultural Revolution, the wave of reform and opening up, the impact of the market economy, and the changes of the new century. They have lost, gained, confused, and determined. But they never gave up - giving up their persistence in medicine, their commitment to their family, and their hope for the future.