Su Qingyuan, the chief medical examiner of the modern era, traveled through an explosion and became a bullied concubine in the palace of the Minister of Rites of the Dajing Dynasty. Originally a coward, he was regarded as a stepping stone by his aunt and uncle, and eventually died in an "accident".
Su Qingyuan, who took over the body, armed with the calmness and knowledge of toxicology of a forensic doctor, was determined not to be manipulated anymore. She cleverly resolved the crisis, punished the evil slaves, and caught her aunt and uncle off guard. By chance, she relied on her precise toxicology analysis to uncover a poisoning plot against Prince Jing Xiao Jue, attracting the attention of this prince who was poisoned with strange poisons and had an unpredictable temperament.
In order to relieve his own cold poison, Xiao Jue took Su Qingyuan under his wings, and the two reached a cooperation: she checked and detoxified him, and he supported her and protected her. However, as they teamed up to solve strange cases again and again - from secret poisons in the harem to assassinations in the court, from old cases to the mystery of the world, Su Qingyuan not only uncovered the truth about the death of her biological mother, but also discovered that Xiao Jue's poison was closely related to a palace coup ten years ago, and her time travel did not seem to be accidental.
In the thrilling game of power and the test of life and death, the cold-faced prince was gradually moved by her intelligence, tenacity and occasional vulnerability, while Su Qingyuan also gradually lowered her guard under Xiao Jue's protection. When hatred, conspiracy, and imperial power struggle surround the two of them, can they protect each other in troubled times? She is his antidote, and he is her destination.