This book tells the story of Ning Yongle, the young master of the No. 1 Martial arts family. He was poisoned by "Erosion Powder" for fifteen years by his third uncle and his chef, and was reduced from a five-year-old prodigy to a sickly waste. On their wedding day, his wife Su Jianxue colluded with her cousin Ning Yonggang to poison her parents and usurp family power. They eventually poisoned Ning Yongle and dumped her in a mass grave.
However, due to the neutralization of the old and new poisons in his body, Ning Yongle accidentally activated the family secret "Hunyuan Yiqi Jue" and became the unparalleled "Hunyuan Poison Evil". He changed his name to Zhang Shitou and returned from hiding with his loyal servants Yongjing and Yongkang. He worked step by step to uncover the conspiracy and settle the blood feud on the day of the family festival.
In order to track down the remaining forces and the mystery of Yongjing's life experience, the three of them went south to fight against the Japanese. Yongjing was recognized by Qi Jiguang as the orphan of Zhang Fulin, a famous anti-Japanese general, and the team won the banner of "An Guoyi Cong". Ning Yonggang defected to Yongjing, the enemy who killed his father, the "Shadow Emperor", and the brothers finally faced off on the battlefield of their home and country. In the end, Ning Yongle and his wife annihilated the national traitors and established Anguo School and Jishi Medical Center along the coast, turning martial arts and medical skills into the firewood of protecting the country.
Su Jianxue, who was mad and wasted, wandered in the countryside, pregnant with Ning Yonggang's unborn son, and was rescued by a mute woodcutter, leaving behind the foreshadowing of the reincarnation of fate.